BioPharma companies have been making some huge strides over the last year with innovations driven by both established players and startups entering the scene. With an impressive 7.32% CAGR and a value of $325.17 billion in 2020 it is a huge industry ripe for growth.
United States is home to a range of established and new BioPharma companies. With a strong foundation & a maturing regulatory space United States offers a wide range of opportunities for BioPharma companies.
This list aims to showcase some of the top BioPharma companies and startups in United States focusing on companies with great track records, innovative products or huge future potential.
Ginkgo Bioworks
Ginkgo Bioworks is a developer of biological engineering products and custom microbes across multiple markets. Based out of Boston, Massachusetts, United States
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Novavax
Novavax is a clinical-stage biotechnology company focused on the discovery and development of innovative vaccines. Based out of Gaithersburg, Maryland, United States
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Marinus Pharmaceuticals
Marinus Pharmaceuticals reformulates, develops, and commercializes drugs to treat neurological, psychiatric, and pain disorders. Based out of Branford, Connecticut, United States
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Datavant
Datavant is a provider of a healthcare data solutions to help institutions share, protect, and match health data. Based out of San Francisco, California, United States
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Ocugen
Ocugen is a clinical stage biopharmaceutical company. Based out of Malvern, Pennsylvania, United States
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Resilience
Resilience provides end-to-end biopharmaceutical manufacturing and development solutions. Based out of La Jolla, California, United States
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Alloy Therapeutics
Alloy Therapeutics is a biotech company that makes medicine by democratizing access to foundational drug discovery platforms and services. Based out of Lexington, Massachusetts, United States
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Triana Biomedicines
Triana Biomedicines is building the leading molecular glue discovery platform to regulate disease. Based out of Waltham, Massachusetts, United States
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PrognomiQ
PrognomiQ is a biotechnology firm that develops test products to detect early disease detection through the power of multi-omics data. Based out of San Mateo, California, United States
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Absci
Absci is the drug & target discovery company harnessing deep learning AI & synthetic biology to expand the therapeutic potential of proteins Based out of Vancouver, Washington, United States
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nference
nference.inc, provides an AI based software platform that synthesizes siloed biomedical knowledge for insights and makes it computable. Based out of Cambridge, Massachusetts, United States
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Sirnaomics
Sirnaomics is a biopharmaceutical company developing therapeutics for critical human diseases by using RNA interference technology. Based out of Gaithersburg, Maryland, United States
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BrightInsight
BrightInsight offers a global regulated digital health platform for biopharma and medtech. Based out of San Jose, California, United States
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Solugen
Solugen is a specialty chemicals manufacturer creating chemistries that are safe, cost-effective, and environmentally-friendly. Based out of Houston, Texas, United States
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Virpax Pharmaceuticals Inc.
Our product candidates are being developed to manage global unmet needs in the areas of cancer and non-cancer pain, PTSD, and CNS Disorder. Based out of Berwyn, Pennsylvania, United States
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Cullinan Oncology
Cullinan Oncology is dedicated to creating new standards of care for patients with cancer. The company uses small molecules and biologics to create differentiated ideas, identify unique targets, and select the optimal modality to develop transformative therapeutics across cancer indications.
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Arcellx
Arcellx is a clinical-stage biotechnology company that provides patients with superior immune cell therapies. Based out of Gaithersburg, Maryland, United States
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Paige
A Global Leader in Digital Diagnostics Based out of New York, New York, United States
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TRex Bio
TRex Bio is a biotechnology company that treats diseases like cancer, fibrotic by studying human tissues. Based out of South San Francisco, California, United States
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Berkeley Lights
Berkeley Lights is a provider of research and development services using micro-droplet technology that change the biological processes. Based out of Emeryville, California, United States
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Cache
Cache is advancing personalized medicine and digital data storage by making storage and access to biomolecules widely accessible. Based out of Foster City, California, United States
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METiS Therapeutics
METiS Therapeutics uses integrated drug discovery to develop medicines in a variety of illness areas. Based out of Cambridge, Massachusetts, United States
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Elastrin Therapeutics
Elastrin Therapeutics is a biotech company developing novel therapies to reverse cardiovascular disease. Based out of Simpsonville, South Carolina, United States
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Roivant Sciences
Roivant Sciences is a biopharmaceutical company focused on the development of medicines and healthcare technologies to patients. Based out of New York, New York, United States
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Regeneron
Regeneron Pharmaceuticals is a biotechnology company that invents life-transforming medicines for people with serious diseases. Based out of Tarrytown, New York, United States
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Ultivue
Ultivue is a biotechnology company that specializes in tissue imaging, diagnostics, and multiplexing. Based out of Cambridge, Massachusetts, United States
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Satellite Bio
Satellite Bio specializes in cell therapy, regenerative medicine, synthetic biology, cell biology, and tissue engineering. Based out of Cambridge, Massachusetts, United States
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Tessera Therapeutics
Tessera Therapeutics is an early-stage life sciences company. Based out of Cambridge, Massachusetts, United States
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Adicet Bio
Adicet Bio is a biotechnology company that designs and develops of off-the-shelf allogeneic gamma delta T cell therapies. Based out of Menlo Park, California, United States
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Axsome Therapeutics
Axsome Therapeutics develops and commercializes therapies for the management and treatment of pain and other neurological disorders. Based out of New York, New York, United States
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CRISPR Therapeutics
CRISPR Therapeutics is focused on the development of transformative medicines using its proprietary CRISPR/Cas9 gene-editing platform. Based out of Cambridge, Massachusetts, United States
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EGenesis
EGenesis focuses on leveraging genome editing technology to deliver safe and effective human transplantable cells, tissues, and organs. Based out of Cambridge, Massachusetts, United States
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Krystal Biotech
Krystal Biotech provide significant clinical benefit for patients suffering from rare debilitating disorders.. Based out of Pittsburgh, Pennsylvania, United States
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Totus Medicines
Totus Medicines is a provider of chemical biology technologies by creating life-changing covalent drugs. Based out of Cambridge, Massachusetts, United States
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Retro Biosciences
Retro Biosciences focus on cellular reprogramming, autophagy and plasma-inspired therapeutics. Based out of San Francisco, California, United States
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Vir Biotechnology
Vir Biotechnology is a clinical-stage immunology company developing therapeutic products to treat and prevent serious infectious diseases. Based out of San Francisco, California, United States
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Arbor Biotechnologies
Arbor Biotechnologies is an operator of a bio-discovery company intended to provide human diagnostic development services. Based out of Cambridge, Massachusetts, United States
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Cytokinetics
Cytokinetics is a biopharmaceutical company developing therapies for debilitating diseases. Based out of South San Francisco, California, United States
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Kadmon
Kadmon Corporation is a biopharmaceutical company offering products and services for the treatment and management of hepatitis C. Based out of New York, New York, United States
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Seres Therapeutics
Seres Therapeutics is a microbiome therapeutics company focused on discovering and developing Ecobiotic therapeutic products. Based out of Cambridge, Massachusetts, United States
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UroGen Pharma
UroGen Pharma is a clinical-stage biopharmaceutical company. Based out of New York, New York, United States
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Stealth BioTherapeutics
Stealth BioTherapeutics is a clinical-stage biotechnology company focused on the discovery and commercialization of novel therapies. Based out of Newton, Massachusetts, United States
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Histogen
Histogen is a regenerative medicine company with a novel biological platform that replaces and regenerates tissues in the body. Based out of San Diego, California, United States
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Tonix Pharmaceuticals Holding
Tonix Pharmaceuticals Holding develops pharmaceutical products for central nervous system disorders. Based out of New York, New York, United States
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Rondo Therapeutics
Therapeutic antibody discovery and development Based out of Hayward, California, United States
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MEI Pharma
MEI Pharma is a San Diego-based oncology company focused on the clinical development of novel therapies for cancer. Based out of San Diego, California, United States
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Cambrian Biopharma
Cambrian is a distributed development company building therapeutics to lengthen health span. Based out of New York, New York, United States
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Silverback Therapeutics
Silverback Therapeutics is a biopharmaceutical company that develops ImmunoTAC therapies targeting previously inaccessible disease pathways. Based out of Seattle, Washington, United States
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Axol Bioscience
Axol Bioscience sells live human cell cultures and provides services such as genome editing to researchers. Based out of Cambridge, Massachusetts, United States
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Verastem Oncology
Verastem is a biopharmaceutical company that focuses on discovering and developing novel drugs that selectively target cancer stem cells. Based out of Needham, Massachusetts, United States
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Tenaya Therapeutics
Tenaya Therapeutics is a developer of novel therapies designed to offer treatment for heart disease. Based out of San Francisco, California, United States
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Prellis Biologics
Prellis employs holographic tissue printing technology with rapid fully human antibody discovery, in vitro human disease and ADME/Tox models Based out of San Francisco, California, United States
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Evofem Biosciences
Evofem is a biotechnology company that develops reproductive and contraceptive care products for women worldwide. Based out of San Diego, California, United States
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NextCure
NextCure is a biopharmaceutical company focused on discovering and developing next generation immuno-oncology-based drugs. Based out of Beltsville, Maryland, United States
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ProPharma Group
ProPharma Group is the independent, single-source provider of regulatory, compliance, pharmacovigilance, and medical information services. Based out of Overland Park, Kansas, United States
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Locus Biosciences
Locus Biosciences develops CRISPR-engineered precision antibacterial platform designed to revolutionize the treatment of bacterial disease. Based out of Morrisville, North Carolina, United States
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ReCode Therapeutics
ReCode Therapeutics is a genetic medicines company developing targeted, disease-modifying therapies for life-limiting respiratory diseases. Based out of Dallas, Texas, United States
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Alto Neuroscience
Alto Neuroscience is a clinical-stage biopharmaceutical company that creates precision medicines through its AI-driven biomarker platform. Based out of Los Altos, California, United States
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Vaxcyte
Vaxcyte focuses on developing vaccines designed to prevent or treat some of the most common and deadly infectious diseases worldwide. Based out of Foster City, California, United States
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Othram
Othram enables human ID from difficult evidence like touch DNA, mixtures, and decades-old bones. Based out of The Woodlands, Texas, United States
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Day One Biopharmaceuticals
Day One Biopharmaceuticals is a biotechnology company that focuses on developing new cancer therapies for patients of all ages. Based out of South San Francisco, California, United States
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KSQ Therapeutics
KSQ Therapeutics is using CRISPR technology within a powerful drug discovery engine to enable high-confidence drug development. Based out of Cambridge, Massachusetts, United States
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OncXerna Therapeutics
OncXerna Therapeutics offers precision medicine using an innovative RNA-based biomarker platform. Based out of Waltham, Massachusetts, United States
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REGENXBIO
REGENXBIO develops adeno-associated viral vector-based therapeutics and research tools, offering NAV, a recombinant AAV-vector. Based out of Rockville, Maryland, United States
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Concerto Biosciences
Concerto Biosciences reinvents humanity's relationship with microbes. Based out of Cambridge, Massachusetts, United States
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Manus Bio
Manus Bio makes nature accessible and affordable for a growing society. Based out of Cambridge, Massachusetts, United States
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3T Biosciences
3T Biosciences is an immunotherapy company headquartered in Menlo Park, California. Based out of Menlo Park, California, United States
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Auraleaf Innovations Inc.
Auraleaf Innovations is a US-based company focused on developing oral care solutions using plant-derived active ingredients. Based out of Cambridge, Massachusetts, United States
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Asklepios BioPharmaceutical
Asklepios BioPharmaceutical is a biotechnology company developing adeno-associated virus (AAV) gene therapies for genetic disorders. Based out of Chapel Hill, North Carolina, United States
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64x Bio
64x Bio builds a platform that increases the speed and scale of mammalian cell line discovery. Based out of San Francisco, California, United States
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HotSpot Therapeutics
HotSpot Therapeutics is a developer of a therapy platform designed to discover medicines and provide proper treatment. Based out of Boston, Massachusetts, United States
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Umoja Biopharma
Umoja Biopharma is a biopharmaceutical company developing next-generation immunotherapies intended to combat cancer. Based out of Seattle, Washington, United States
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Epizyme
Epizyme is a biopharmaceutical company focusing on treatments for blood cancer and tumors. Based out of Cambridge, Massachusetts, United States
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Theravance Biopharma
Theravance Biopharma is a biopharmaceutical company with one approved product. Based out of South San Francisco, California, United States
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Zerigo Health
Clarify Medical is a developer of a handheld medical device used to treat psoriasis, eczema, and vitiligo . Based out of La Jolla, California, United States
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Zentalis Pharmaceuticals
Zentalis is a clinical-stage biopharmaceutical company focused on developing clinically differentiated, novel small molecule therapeutics. Based out of New York, New York, United States
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HDT Bio
IMMUNE THERAPY FOR ALL: We’re transforming inventive immunotherapies for oncology and infectious disease. Based out of Seattle, Washington, United States
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CAMP4 Therapeutics
CAMP4 Therapeutics is a biotechnology company that uses RNA to restore healthy gene expression. Based out of Cambridge, Massachusetts, United States
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Unlearn.AI
Unlearn.AI develops a platform to accelerate clinical trials for Alzheimer's Disease, Multiple Sclerosis, and other complex diseases. Based out of San Francisco, California, United States
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Demetrix
Demetrix is a biotechnology company that manufactures natural medicines using synthesis biology to make medical drugs. Based out of Emeryville, California, United States
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Elevation Oncology
Elevation Oncology is a clinical-stage biopharmaceutical company focused on the development of precision medicines for patients. Based out of New York, New York, United States
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Infinity Pharmaceuticals
Infinity Pharmaceuticals engages in the discovery and development of medicines for the treatment of cancer and related conditions. Based out of Cambridge, Massachusetts, United States
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Sagimet Biosciences
Sagimet Biosciences is a biotechnology company that focuses on developing novel therapeutics to treat important diseases. Based out of San Mateo, California, United States
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Arrakis Therapeutics
Arrakis Therapeutics is a biopharmaceutical developing drugs for neurological disorders and other diseases. Based out of Waltham, Massachusetts, United States
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Zosano Pharma
Zosano Pharma is a biopharmaceutical company, develops products based on the transdermal delivery technology. Based out of Fremont, California, United States
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LatchBio
Latch Bio builds and disseminates free to use data infrastructure for the the biocomputing revolution. Based out of San Francisco, California, United States
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Aadi Bioscience
Aadi Bioscience develops a potentially mTOR inhibitor for targeted patient populations in oncology and cardiovascular diseases. Based out of Pacific Palisades, California, United States
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Geron
Geron Corp. operates as a biopharmaceutical company which discovers and develops therapeutic products for cancer. Imetelstat, a novel, Based out of Menlo Park, California, United States
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NGM Biopharmaceuticals
NGM Biopharmaceuticals is a drug discovery company developing biotherapeutics for the gastrointestinal endocrine system. Based out of South San Francisco, California, United States
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Cassava Sciences
Cassava Sciences is a clinical-stage biopharmaceutical company focused on neuroscience. Based out of Austin, Texas, United States
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Viracta Therapeutics
Viracta Therapeutics is a precision oncology company focused on new treatment of virus-associated malignancies. Based out of Cardiff By The Sea, California, United States
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Palisade Bio
Palisade Bio is a clinical-stage biopharmaceutical company developing novel treatments for diseases of unmet medical need. Based out of Germantown, Maryland, United States
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Dynavax Technologies
Dynavax Technologies is a biopharmaceutical company discovering and developing novel products to prevent and treat infectious diseases. Based out of Berkeley, California, United States
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Aptinyx
Aptinyx Inc. is a biopharmaceutical company. Based out of Evanston, Illinois, United States
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Arcutis Biotherapeutics
Arcutis Biotherapeutics is a clinical-stage biopharmaceutical company focused on developing medical dermatology for unmet needs. Based out of Westlake Village, California, United States
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Apexigen
Apexigen is a biopharmaceutical product development company developing products to address life-threatening and difficult to treat diseases. Based out of Burlingame, California, United States
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NexImmune
NexImmune is a biopharmaceutical company developing novel immuno-therapeutics based on the proprietary artificial immune technology. Based out of Gaithersburg, Maryland, United States
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ACELYRIN
ACELYRIN is a biopharma company that identifies, acquires, and accelerates the development and commercialization of life-changing therapies. Based out of Los Angeles, California, United States
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Mirati Therapeutics
Mirati Therapeutics is a Biotechnology company located in 9363 Towne Centre Dr, San Diego, CA, United States. Based out of San Diego, California, United States
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Blade Therapeutics
Blade Therapeutics is a discovery stage drug development company. Based out of South San Francisco, California, United States
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Intra-Cellular Therapies
Intra-Cellular Therapies develops drugs for the treatment of neuropsychiatric and neurologic diseases, and other disorders of the CNS. Based out of New York, New York, United States
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